Lobo is a surname found in the Galician, Spanish and Portuguese languages meaning "wolf", and in other languages with other meanings. Notable people with the surname include:

• Almiro Lobo (born 1982), known as Miro, Mozambican football defender
• Alonso Lobo (1555–1617), Spanish composer of the late Renaissance
• Amberley Lobo (born 1990), Australian television presenter
• Anthony Theodore Lobo (1937–2013), Pakistani Roman Catholic bishop
• António Lobo de Almada Negreiros (1868–1939), Portuguese journalist, colonialist writer, essayist and poet
• Baltasar Lobo (1910–1993), Spanish artist, anarchist and sculptor
• Cavin Lobo (born 1988), Indian footballer
• Claude Lobo (1943–2011), French car designer
• Cristiana Lôbo (1957–2021), Brazilian journalist
• Cristiana Lobo (swimmer) (born 1972), Brazilian swimmer
• Duarte Lobo (1565–1646), Portuguese composer of the late Renaissance
• Edu Lobo (born 1943), Brazilian singer, guitarist, and composer
• Emerico Lobo de Mesquita (1746–1805), Brazilian composer, music teacher, conductor and organist
• Emiro Lobo (1948–2007), Venezuelan painter, graphic artist and designer
• Erik Lobo (born 1970), known as Mr Lobo, American artist and comedic actor
• Eugenio Gerardo Lobo (1679–1750), Spanish soldier and poet
• Francisco Miranda da Costa Lobo (1864–1945), Portuguese astronomer, pioneer of spectrography
• Francisco Rodrigues Lobo (1580–1622), Portuguese poet and bucolic writer
• Ignatius P. Lobo (1919–2010), Indian prelate of the Catholic Church
• Ildo Lobo (1953–2004), Cape Verdean singer
• Jerónimo Lobo (1593–1678), Portuguese Jesuit missionary
• Julio Lobo (1898–1983), Cuban sugar trader and financier
• Leonard D. Lobo, former headmaster of St Columba's School, Delhi, India
• Luis Lobo (born 1970), Argentine professional tennis player
• Mario Humberto Lobo (born 1964), Argentine former footballer
• Mary Kay Lobo (born 1975), American psychiatric neuroscientist
• Michael Lobo (born 1953), Indian Catholic scientist and genealogist
• Michael Lobo (politician) (born 1976), Indian politician
• Nahuel Lobo (born 1991), Argentine rugby union footballer
• Pedro Lobo (born 1954), Brazilian photographer
• Porfirio Lobo Sosa (born 1947), President of Honduras
• Rebecca Lobo (born 1973), American television basketball analyst and former professional basketball player
• Ricardo Lobo (born 1984), Brazilian football striker
• Rogerio Hyndman Lobo (1923–2015), Macanese businessman
• Rogerio Lobo (boxer) (1971–2006), Brazilian professional boxer
• Sascha Lobo (born 1975), German blogger, writer, journalist and copywriter
• Stephen Lobo (born 1973), Canadian actor