William Wynn or William Wynne may refer to:
- William Wynne (historian) (c. 1671–1704), priest and historian
- William Wynne (MP for Caernarvon), (1678–1754), MP for Caernarvon, 1749-1754
- William Wynne (lawyer) (c. 1692–1765), lawyer and writer
- William Wynn (poet) (c. 1709–1760), Welsh priest and poet
- William Wynne (judge) (1729–1815), English lawyer, Dean of Arches and Master of Trinity Hall, Cambridge
- William Wynne (Irish politician) (c 1764–1855), Irish politician, MP for Sligo Borough 1799–1800
- William Watkin Edward Wynne (1801–1880), MP for Merionethshire (1852–1865) and antiquarian
- William J. Wynn (1860–1935), Member of the US House of Representatives from California
- William Andrew Wynne (1869–1951), baseball pitcher, played one Major League game for the Washington Senators
- William Wynn (footballer) (1876–1944), Shrewsbury Town F.C. and Wales international footballer
- William Robert Maurice Wynne (died 1909), MP for Merionethshire 1865–1868
- Will Wynn (American football) (born 1949), defensive end for the Philadelphia Eagles and the Washington Redskins
- Will Wynn (born 1961), Mayor of Austin, Texas
- William Wynne (athlete) (born 1990), American hurdler
- William H. Wynn, trade unionist and first president of the United Food and Commercial Workers International Union
- Bill Wynne, American author and dog trainer
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