William Cohen (born 1940) is an American author and politician who served as Secretary of Defense (1997–2001) under Bill Clinton.
William Cohen may also refer to:
- William W. Cohen (1874–1940), U.S. Representative from New York
 - William Edgar Cohen (1941–2014), filmmaker
 - William D. Cohen, associate justice of the Vermont Supreme Court
 
See also
- William D. Cohan (born 1960), newspaper reporter
 - Bill Coen, basketball coach
 - Billy Coen, fictional Resident Evil character
 
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