Holtzendorff or von Holtzendorff can refer to:
- Holtzendorff (noble family) (German: (pl.) die Herren von Holtzendorff), a Brandenburgian (Old Märkisch) noble family, an Uradel der Uckermark, later Silesia, Ostpreußen, Pommerania, Royal Saxony, and Mecklenburg.
 - Georg Holtzendorff, 19th-century German painter
 - Henning von Holtzendorff (1853–1919), a German admiral
 - Joachim Wilhelm Franz Philipp von Holtzendorff (1829–1889), a German jurist
 
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