Tom, Thomas or Tommy Keene may refer to:
- Tom Keene (actor) (1896–1963), American film actor
- Tom Keene (radio host) (born 1952), American radio host associated with Bloomberg Radio
- Tommy Keene (1958–2017), American singer-songwriter
- Thomas W. Keene (1840–1898), American stage actor
- Thomas G. Keen, American Baptist minister
See also
- "Tom Keen", an episode of the crime drama The Blacklist
- Tom Kean (disambiguation)
- Thomas Keane (disambiguation)
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