Tickle is an English toponymic surname, derived from Tickhill in Yorkshire. Notable people with the surname include:
- Charlie Tickle (1883 – after 1919), English footballer
 - Cheryll Tickle, British biologist
 - Danny Tickle (born 1983), English rugby league footballer
 - David Tickle, British record producer and engineer
 - Gerard William Tickle (1909–1994), English prelate
 - Jon Tickle (born 1974), British TV presenter
 - Phyllis Tickle (1934–2015), American author and lecturer
 - Sam Tickle (born 2002), English professional footballer
 - Steven Ray Tickle, American television personality on Moonshiners and Tickle.
 
See also
- Tickle (disambiguation)
 - Mr. Tickle, the first book in the Mr. Men series by Roger Hargreaves
 - Tickell
 
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