The Lion and the Mouse is one of Aesop's Fables.

The Lion and the Mouse may also refer to:

• The Lion and the Mouse, a 1905 play by Charles Klein
• The Lion and the Mouse (1914 film), a lost 1914 silent film drama
• The Lion and the Mouse (1919 film), a lost silent film directed by Tom Terriss
• The Lion and the Mouse (1928 film), a film based on Klein's play
• The Lion & the Mouse, a 2009 children's book by Jerry Pinkney
• The Lion and Mouse, a sculpture by Marshall Fredericks