Sean O'Brien may refer to:
Sportspeople
- Seán O'Brien (Gaelic footballer), Gaelic footballer for Nemo Rangers
- Seán O'Brien (Cork hurler) (1926–?), Irish hurler
- Seán O'Brien (Tipperary hurler), Irish hurler
- Sean O'Brien (ice hockey) (born 1972), American former ice hockey left winger
- Seán O'Brien (rugby union, born 1987), Irish rugby union international flanker for Leinster and London Irish
- Seán O'Brien (rugby union, born 1994), Irish rugby union flanker for Connacht
- Seán O'Brien (rugby union, born 1998), Irish rugby union centre for Connacht
- Seán O'Brien (rugby union, born 2000), American-born Irish rugby union flanker for Leinster
- Sean O'Brien (windsurfer) (born 1984), Australian windsurfer
- Sean O'Brien (footballer), English footballer
Other people
- Sean O'Brien (writer) (born 1952), British writer
- Sean C. O'Brien, co-discoverer of buckminsterfullerene
- Sean O'Brien (labor leader), American trade unionist
- Sean O'Brien (musician), bassist and original member of Boston rock band Come
- Sean O'Brien (Ohio politician) (born 1969), Democratic member of the Ohio Senate
See also
- John O'Brien (disambiguation)
- Sean O'Bryan (born 1963), American actor
- Shaun O'Brien (disambiguation)
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