Rock Island Line may refer to:
- Rock Island Line, the traditional song
 - Chicago, Rock Island and Pacific Railroad, believed to be the line mentioned in the traditional song
 - Rock Island District, the Metra commuter rail line
 - Rock Island Line (album), the Johnny Cash album
 
See also
- Rock Island Clean Line, an electrical distribution trunk line in the U.S. Midwest
 - Rock Island Southern Railway, Illinois, USA
 - Peoria and Rock Island Railroad, Illinois, USA
 - Rock Island (disambiguation)
 - Island Line (disambiguation)
 
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