Manuel Rodríguez may refer to:
Sports
- Manolete (Manuel Rodríguez Sánchez, 1917–1947), Spanish bullfighter
 - Manuel Rodríguez Barros (1926-1997), Spanish cyclist
 - Manuel Rodríguez (footballer) (1938–2018), Chilean footballer
 - Manuel Rodríguez Navarro (born 1969), Spanish wheelchair basketball player
 - Manuel Cristian Rodríguez (boxer) (born 1973), Argentine boxer
 - Manuel Rodríguez (first baseman) (born 1985), Panamanian baseball player
 - Manu Rodríguez (born 1991), Spanish basketball player
 - Manuel Rodríguez (pitcher) (born 1996), Mexican baseball player
 - Manuel Rodríguez (tennis), Chilean tennis player
 
Others
- Manuel Rodríguez Erdoíza (1785–1818), Chilean lawyer and guerrilla leader
 - Manuel Rodríguez Lozano (1896–1971), Mexican painter
 - Manuel Rodríguez Orellana (born 1948), Puerto Rican legal scholar, lawyer, lecturer, columnist, published poet and political leader
 - Manuel Rodríguez Ramos (born 1908), Puerto Rican writer, law professor and Secretary of Justice of Puerto Rico
 - Manuel Rodríguez Torices (1788–1816), Neogranadine statesman, lawyer, journalist, and Precursor of the Independence of Colombia
 - Manuel Rodríguez Gómez (1928–2006), American neurologist most noted for his work on tuberous sclerosis, a rare genetic disorder
 - Manuel Rodríguez Cuadros (born 1949), Peruvian diplomat and presidential candidate
 
Other uses
- Manuel Rodríguez Patriotic Front, left-wing guerrilla movement in Chile
 - Manuel Rodriguez Island, an island in the Patagonian Archipelago in Magallanes y la Antártica Chilena Region, Chile
 - Manuel Rodríguez (TV series), a 2010 Chilean telenovela broadcast in Chilevisión, based on the Chilean guerrilla Manuel Rodríguez Erdoiza
 
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