MSSA may refer to:
- Member of the Order of the Star of South Africa
 - Methicillin-sensitive Staphylococcus aureus, a subspecies of bacterium
 - Military Selective Service Act, a law establishing the current Selective Service System in the United States
 - Military-style semi-automatic, a firearm (abbreviation commonly used in New Zealand)
 - Mind Sports South Africa
 - Montreal Student Space Associations
 - MSSA Chemical company, a French chemical company, also known as Métaux Spéciaux
 - Master of Science in Social Administration, master's degree from the Mandel School at Case Western Reserve University, equivalent to a master of social work
 - Multi-channel/-variate Singular spectrum analysis, an extension of the SSA technique
 
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