MSH may refer to:
Biology and medicine
- Melanocyte-stimulating hormone, a hormone produced in the pituitary gland, and related to skin pigmentation
 - DNA mismatch repair genes:
 - Multiple system atrophy
 - Mycothiol, an unusual thiol that is found in Actinobacteria
 
Computing
- Microsoft Surface Hub
 - Monad Shell (msh), a former name for the Microsoft Windows PowerShell
 
Places
- Maharashtra state highway, India
 - Markham Stouffville Hospital, Ontario, Canada
 - RAFO Masirah airport, Oman (IATA: MSH)
 - Mississippi State Hospital, US
 - Mossley Hill railway station, England
 - Mount St. Helens, volcano in Washington, US
 - Mount Sinai Hospital, Toronto, Canada
 
Other uses
- Maison des Sciences de L'Homme, a research foundation in Paris, France
 - Management Sciences for Health, a non-profit
 - Marvel Super Heroes (disambiguation), in entertainment
 - Masikoro language, spoken in Madagascar (ISO 639: msh)
 
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