MOF may refer to:
- Managed Object Format, a textual representation of the Distributed Management Task Force (DMTF) Common Information Model (CIM)
- Meta-Object Facility, a meta-model used to formally define Unified Modeling Language (UML)
- Metal–organic framework, a chemical compound formed of metal ions and organic chemical components
- Midlothian Oat Flour, a brand of gruel; see Scott's Porage Oats
- Multiple organ failure, alternate term for Multiple organ dysfunction syndrome, a medical condition
- Microsoft Operations Framework, a set of operational guidelines based on ITIL
- Meilleur Ouvrier de France ("Best Worker of France"), a French competition for artisanal mastery
- Ministry of finance, a government department headed by a finance minister, responsible for tax collection and other money-related activities
- Mountain of Faith, the tenth game in the Touhou series of shoot 'em up games
- Monsters of Folk, an American folk group
- Mof, a Dutch slur referring to Germans
- MOF, IATA airport code for Frans Seda Airport, on the island of Flores in Indonesia
- Museum of Flight, air and space museum in Seattle, United States of America
- Madden Online Football, an online madden league created in 2003, United States of America.
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