MLE may refer to:
Organizations
- Media Lab Europe, former lab in Dublin, Ireland
- Major League Eating, competitive eating organization
- Marxistisk-Leninistisk Enhedsforbund, a Danish Maoist group 1972–1975
- Military Liaison Element anti-terrorist special forces in US embassies
Science and technology
- Mars Lander Engine of Mars Science Laboratory
- Multi-Lamellar Emulsion, in dermatology
- Maximum likelihood estimation, in statistics
- Managed learning environment, in e-learning
- Muconate lactonizing enzyme, in molecular biology
- Magazine Lee–Enfield, a rifle
- Maleless protein, involved in Dosage compensation in Drosophila, in genetics
- An error in Competitive programming meaning Memory Limit Exceeded.
- Machine learning engineer, a software engineer who specializes in machine learning
Other uses
- Magister Legum Europae, i.e. Master of European Law, a European Master's degree in the field of European law
- Multicultural London English, in linguistics
- Velana International Airport, Malé, IATA code
- Mid-Level Exception, an NBA salary cap exception
- Model Law Engineer, a professional designation in the United States
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