MEF may stand for:
Military
- Malaita Eagle Force, a militant organization originating in the island of Malaita in the Solomon Islands
 - Marine Expeditionary Force (MEF), one of the major deployable subdivisions of the United States Marine Corps; see 1st Marine Expeditionary Force, 2nd Marine Expeditionary Force, 3rd Marine Expeditionary Force
 - Mediterranean Expeditionary Force
 - Mesopotamian Expeditionary Force during the First World War
 
Organizations
- Mahratta Education Fund, Indian non-profit organisation
 - Major Economies Forum on Energy and Climate Change
 - Media Education Foundation
 - MEF International School Istanbul
 - Middle East Forum, an American conservative think tank
 - Ministerio de Economía y Finanzas, the Uruguayan ministry of economics and finance
 - Ministero dell’Economia e delle Finanze, the Italian ministry of economics and finance
 - Ministry of Environment and Forests, India
 
Science/technology
- Managed Extensibility Framework, a software plugin framework, written by Microsoft
 - Maximum Elevation Figure (flying)
 - Maximal expiratory flow, another name for peak expiratory flow in spirometry
 - Medial eye fields
 - Metro Ethernet Forum
 - Modernized e-File (MeF), an electronic system for filing U.S. income taxes
 - Modified Energy Factor (Energy Star Rating Value, US Department of Energy (DOE))
 - Mouse Embryonic Fibroblast
 - Museo Paleontológico Egidio Feruglio collection code
 - Myocyte Enhancer Factor (2)
 - Mouse Embryonic Fibroblast (MEF) Isolation Enzyme 1
 - Multiscale Electrophysiology Format, a data format used in electrophysiology
 
Transport
- Mei Foo station, Hong Kong, MTR station code
 
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