M42 or M-42 may refer to:
In science:
- Messier 42, a nebula also called the Orion Nebula
 - the 42nd Mersenne prime, 225964951-1, discovered in 2005
 - an Y-chromosomal mutation, see Haplogroup B-M42
 
In transportation:
- M42 motorway, a motorway in the United Kingdom
 - M-42 (Michigan highway), a state highway in Michigan
 - M42 (Cape Town), a Metropolitan Route in Cape Town, South Africa
 - M42 (Pretoria), a Metropolitan Route in Pretoria, South Africa
 - M42 (New York City bus), a New York City Bus route in Manhattan
 - BMW M42, a 1989 automobile piston engine
 - Dodge M42, ¾-ton command truck, 1950s
 - M42 (sub-basement), a power station at New York City's Grand Central Terminal
 
In photography:
- M42 lens mount, a standard for cameras
 
In firearms and military equipment:
- Ag m/42, a Swedish semi-automatic rifle which saw limited use by the Swedish Army from 1942 until the 1960s
 - M42 Duster, a United States Army self-propelled anti-aircraft gun
 - M42 (gas mask), a United States military gas mask
 - M/42 (bicycle), a Swedish military bicycle
 - 45 mm anti-tank gun M1942 (M-42), a Soviet anti-tank gun (Motovilikha Plants)
 - Duperite M42 helmet, an Australian WWII helmet
 - M42 Stahlhelm, a type of German WWII helmet
 - M42, a Smith & Wesson hammerless revolver
 - M42 United Defense submachine gun, an American weapon used in World War II
 - M42 command truck
 
In manufacturing:
- M42 is the Unified numbering system code ("miscellaneous nonferrous metals and alloys") for a grade of high-speed steel with cobalt
 
See also
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