| Language(s) | Irish | 
|---|---|
| Origin | |
| Derivation | Ó Briain | 
| Meaning | descendant of Brian | 
| Region of origin | Munster, Ireland | 
O'Brien is a surname of Irish origin. It has many variants in the Irish diaspora worldwide, such as Brien, O'Bryan, O'Brian, Brian, O'Brine and O'Bryen which all claim a general common ancestry. The original Gaelic surname is Ó Briain (plural, Uí Briain). Notable people with the name include:
As surname
A
- Aidan O'Brien (b. 1969), Irish race horse trainer
 - Aiden O'Brien, Irish football player
 - Alan O'Brien, Irish association football player
 - Alex O'Brien (b. 1970), professional American tennis player
 - Ambrose O'Brien
 - Andy O'Brien (disambiguation), various
 - Anne O'Brien (disambiguation), various
 - Arthur O'Brien
 - Austin O'Brien
 
B
- Barry O'Brien
 - Billy O'Brien (baseball) (1860–1911), American baseball player
 - Billy O'Brien (footballer), Welsh association football player
 - Brendan O'Brien (disambiguation), various
 - Brenna O'Brien
 - Brock O'Brien
 - Buck O'Brien
 - Burton O'Brien
 
C
- Cathy O'Brien (athlete) (b. 1967), American long-distance runner
 - Cathy O'Brien (conspiracy theorist) (b. 1957), purported American child-slave/sex-abuse victim
 - Charles O'Brien (disambiguation), various
 - Christian O'Brien (1914-2001), British geologist, author & historian
 - Ciaran O'Brien
 - Cinders O'Brien
 - Clinton O'Brien (b. 1974), Australian rugby league footballer
 - Conal O'Brien
 - Conan O'Brien (b. 1963), US comedian and talk show host
 - Connor O'Brien (disambiguation)
 - Conor O'Brien (disambiguation), various
 - Cubby O'Brien
 
D
- Daniel O'Brien (disambiguation), various
 - Danielle O'Brien
 - Danny O'Brien (disambiguation), various
 - Dara Ó Briain, Irish comedian and presenter
 - Darcy O'Brien (1939–1998), American true crime author
 - Daryl O'Brien (b. 1941), Australian footballer (Australian rules football)
 - Dave O'Brien (actor) (1912–1969), American film actor
 - Dave O'Brien (sportscaster), American sportscaster
 - David O'Brien (disambiguation), various
 - Doug Brien (born 1970), former American football placekicker
 - Don Brien (born 1959), Canadian sprint canoer, who competed in the mid to late 1980s
 - Declan O'Brien, president of Utopia Pictures & Television, and a writer and producer
 - Declan O'Brien (footballer)
 - Dennis O'Brien (disambiguation), various
 - Derek O'Brien (disambiguation), various
 - Dermod O'Brien (1865–1906), Irish painter
 - Donald O'Brien (disambiguation), various
 - Doug O'Brien
 - Dylan O'Brien (b. 1991), American actor
 
E
- Ed O'Brien (b. 1968), English musician
 - Edmond O'Brien (1915–1985), American actor
 - Edna O'Brien (b. 1930), Irish novelist
 - Edward O'Brien (disambiguation), various
 - Edwin Frederick O'Brien, Grand Master of the Equestrian Order of the Holy Sepulchre of Jerusalem
 - Eileen O'Brien (disambiguation), various
 - Elaine O'Brien, American politician
 - Erin O'Brien (writer), American writer
 - Erin Joanne O'Brien (1934–2021), American actress
 - Eugene O'Brien (disambiguation), various
 
F
- Fergal O'Brien, Irish professional snooker player
 - Fergus O'Brien (1930–2016), Irish politician
 - Fitz James O'Brien, Irish born American novelist
 - Flann O'Brien, pen name of Irish novelist and satirist Brian O'Nolan
 
G
H
- Harry O'Brien (changed his name in 2013 to "Heritier Lumumba")
 - Harry J. O'Brien
 - Helen O'Brien (1925–2005), British nightclub owner and spy
 - Henry O'Brien (disambiguation), various
 - Hod O'Brien (1936–2016), American jazz pianist
 - Hugh O'Brien (1827–1895) mayor of Boston
 
I
- Iain O'Brien
 - Ian O'Brien
 - Ignatius O'Brien, 1st Baron Shandon (1857–1930), Lord Chancellor of Ireland, 1913–1918
 
J
- Jack O'Brien (disambiguation), various
 - Jake O'Brien (fighter), MMA fighter
 - Jake O'Brien (footballer), Irish footballer
 - James O'Brien (disambiguation)
 - Jamie O'Brien (disambiguation), various
 - Jeremiah O'Brien (1744–1818), US Navy officer of the American Revolutionary War
 - Jesse O'Brien (disambiguation), various
 - Jim O'Brien (disambiguation)
 - Joan O'Brien
 - Joe O'Brien (disambiguation), various
 - Joey O'Brien
 - John O'Brien (disambiguation), various
 - Joseph O'Brien (disambiguation), various
 
K
- Kate O'Brien (disambiguation)
 - Katharine O'Brien
 - Katherine O'Brien
 - Kathleen O'Brien
 - Katie O'Brien, British female tennis player
 - Keith O'Brien (1938-2018), Roman Catholic Cardinal Archbishop of Saint Andrews and Edinburgh
 - Ken O'Brien
 - Kerry O'Brien (disambiguation)
 - Kevin O'Brien (disambiguation), various
 - Kieran O'Brien
 - Kim O'Brien, American film and television actress
 - Kirsten O'Brien (born 1972), British TV presenter
 - Kitt O'Brien (born 1990), American football player
 - Kitty Wilmer O'Brien, Irish painter
 
L
- Larry O'Brien (1917–1990), American politician
 - Larry O'Brien (Canadian politician), Canadian entrepreneur and politician; Mayor of Ottawa, 2006–2010
 - Laurence O'Brien
 - Lawrence D. O'Brien
 - Leighton O'Brien
 - Lévis Brien (born 1955), Quebec politician
 - Leo O'Brien (disambiguation), various
 - Leonora O'Brien, Irish pharmacist and entrepreneur
 - Leslie O'Brien
 - Liam O'Brien (disambiguation), various
 - Lucy O'Brien
 - Luke O'Brien
 
M
- Margaret O'Brien
 - Mariah O'Brien
 - Mark O'Brien (disambiguation), various
 - Mary Eileen O'Brien, American academic administrator
 - Matthew O'Brien (1814-1855), Irish mathematician
 - Maureen O'Brien
 - Michael O'Brien (disambiguation), various
 - Michele O'Brien
 - Mick O'Brien (disambiguation), various
 - Mike O'Brien (hurler)
 - Miles O'Brien (disambiguation), various
 - Mollie O'Brien
 
N
O
- Olivia O'Brien (born 1999), American singer and songwriter
 
P
- Paddy O'Brien (disambiguation), various
 - Parry O'Brien
 - Patricia Salas O'Brien (born 1958), Peruvian sociologist and Minister of Education
 - Patrick O'Brien (disambiguation), for people with forename Patrick or Pat
 - Pat O'Brien (disambiguation), various
 - Paul O'Brien (disambiguation), various
 - Peter O'Brien (disambiguation), various
 - Phil O'Brien (disambiguation), several people
 
R
- Raymond O'Brien, American Roman Catholic priest
 - Richard O'Brien (disambiguation), various
 - Riley O'Brien, American baseball player
 - Robert O'Brien (disambiguation), various
 - Rory Brien
 - Ron O'Brien (disambiguation), various
 - Roy O'Brien
 
S
- Scott O'Brien
 - Sean O'Brien (disambiguation)
 - Shane O'Brien (disambiguation), various
 - Shannon O'Brien
 - Sicele O'Brien, Irish aviator
 - Simon O'Brien (disambiguation), various
 - Soledad O'Brien, American television journalist
 - Stephen O'Brien, UK conservative politician for Eddisbury
 - Stuart O'Brien (1906–2004), American film editor
 - Stuart O'Brien (stage) (1833–1883), Australian actor
 
T
- Terence O'Brien (disambiguation), various
 - Thomas O'Brien (disambiguation), various
 - Tim O'Brien (disambiguation), various
 - Timothy O'Brien (theatre designer) (1929–2022), British theatre designer
 - Timothy O'Brien (endocrinologist), Irish professor
 - Timothy L. O'Brien (born 1961), American journalist
 - Tina O'Brien (born 1983), English actress
 - Tom O'Brien (actor) (b. 1965), American film actor
 - Tom O'Brien (American football) (b. 1948), American college football coach at North Carolina State University
 - Tom O'Brien (outfielder) (1873–1901), baseball outfielder
 - Tom O'Brien (second baseman) (1860–1921), 19th century baseball player
 - Tom O'Brien (trade unionist) (1900–1970), British trade unionist and Member of Parliament
 - Tommy O'Brien (baseball) (1918–1978), baseball outfielder
 
U
- Una O'Brien, British civil servant
 
V
W
- Walter O'Brien, Computer expert and Irish businessman
 - Walter A. O'Brien, American Progressive Party politician
 - William O'Brien (disambiguation), various
 - Willis H. O'Brien (1886–1962), American motion picture special effects pioneer
 
Z
- Zach O'Brien, professional ice hockey player
 
As first or middle names
- O'Brien Alston (b. 1965), American former football linebacker
 - O'Brien Schofield (b. 1987), American former football linebacker
 - O'Brien Smith (c. 1756 – 1811), Irish-American political figure
 
Fictional people named O'Brien
- O'Brien, a character in George Orwell's novel Nineteen Eighty-Four
 - Lady Cassandra O'Brien, fictional character, Doctor Who antagonist
 - Chloe O'Brian, a fictional character played by actress Mary Lynn Rajskub on the US television series 24
 - Graham O'Brien, a companion of the Thirteenth Doctor in the BBC series Doctor Who
 - Keiko O'Brien, fictional character, wife of Miles O'Brien in Star Trek: The Next Generation and Deep Space Nine
 - Miles O'Brien, a fictional character in Star Trek: The Next Generation and Deep Space Nine
 - Sarah O'Brien, a fictional character on the ITV series Downton Abbey
 - Shelia O'Brian, a character from the animated TV series Dungeons and Dragons
 - Mr. O'Brien, Mrs. O'Brien and Jack O'Brien, fictional characters in The Tree of Life film
 
See also
- O'Brien dynasty, the royal dynasty who ruled Thomond
 
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