LRU may refer to:
Organisations
- Latvian Russian Union, a political party in Latvia
- Lenoir–Rhyne University, US
- Lithuanian Riflemen's Union, a paramilitary organisation in Lithuania
- London Reform Union, a former campaigning group of the Progressive Party
Other uses
- Lance-roquettes unitaire, a variant of M270 Multiple Launch Rocket System in service of French Army
- Las Cruces International Airport (IATA code), US
- Least recently used, a cache replacement algorithm
- The least recently used page replacement algorithm in virtual memory management
- Liberties and Responsibilities of Universities, a French law voted in 2007
- Line-replaceable unit, a modular component of an airplane or other manufactured device
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