Karen Williams may refer to
- Karen Williams (soprano), American concert and opera soprano
 - Karen J. Williams (1951–2013), Chief Judge of the United States Court of Appeals for the Fourth Circuit
 - Karen Lynn Williams (born 1952), American writer of children's literature
 - Karen L. Williams, American diplomat
 - Karen M. Williams (born 1963), American federal judge in New Jersey
 - Karen Hastie Williams (1944–2021), American lawyer and company director
 
See also
- Karyn Williams, American Christian musician
 
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