James Cobb may refer to:
- James Cobb (librettist) (1756–1818), English librettist
 - James E. Cobb (1835–1903), Alabama congressman in the U.S. House of Representatives
 - James A. Cobb, African-American lawyer, judge, and civil rights activist
 - Jimmy Cobb (1929–2020), American jazz musician
 - J. R. Cobb (James Barney Cobb Jr., 1944–2019), American guitarist and songwriter
 - Jim Cobb, American politician in the Tennessee House of Representatives
 
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