Duchy of Tuscany may refer to the following central Italian territories:
- Tuscia, historical region in Central Italy
 - Duchy of Tuscia (576–797), Lombard duchy
 - March of Tuscany (812–1197), frontier march of the Holy Roman Empire
 - Duchy of Florence (1532–1569)
 - Grand Duchy of Tuscany (1569–1859)
 
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