Douglass is a surname. Notable people with the surname include:
- Abel Douglass (before 1849 – c. 1907), American whaler
 - A. E. Douglass (1867–1962), American astronomer
 - Astyanax Douglass (1897–1975), Major League Baseball catcher for the Cincinnati Reds
 - Bill Douglass (1923–1994), American jazz drummer
 - Bobby Douglass (born 1947), American football quarterback for the Chicago Bears
 - Brooks Douglass (1963–2020), American lawyer, politician, and actor
 - Charles Douglass (1910–2003), American sound engineer, credited as the inventor of the laugh track
 - Charles Remond Douglass (1844–1920), African-American clerk and soldier
 - Dale Douglass (1936–2022), American professional golfer
 - David Douglass (physicist), American physicist
 - David Douglass (1720–1786), British-American stage actor and theatre manager
 - David John Douglass, British trade unionist, political activist and writer
 - Dorothea Lambert Chambers (née Douglass, 1878–1960), English tennis player
 - Frank Douglass (1875–1972), South African rugby union player
 - Frederick Douglass (1818–1895), American abolitionist and writer
 - Gregory Douglass (born 1980), American singer-songwriter
 - Gordon K. (Sandy) Douglass (1904–1992), American racer, designer, and builder of sailing dinghies
 - Harry Douglass, Baron Douglass of Cleveland (1902–1978), British trade unionist
 - Herbert E. Douglass (1927–2014), American Seventh-day Adventist theologian
 - Jack Douglass, American internet personality, musician and comedian on YouTube
 - James Nicholas Douglass (1826–1898), English civil engineer, lighthouse builder and designer
 - James W. Douglass, American author, activist, and Christian theologian
 - Jimmy Douglass, American recording engineer and record producer
 - Joe Douglass (born 1974), American football player for the Las Vegas Gladiators
 - John J. Douglass (1873–1939), member of the United States House of Representatives from Massachusetts
 - John Patrick Douglass (born 1988), YouTuber known as "jacksfilms"
 - John Thomas Douglass (1847–1886), American violinist, composer of Virginia's Ball
 - John W. Douglass (born 1941), United States Air Force officer
 - John Watkinson Douglass (1827–1909), American politician
 - Joseph Douglass (1871–1935), African-American concert violinist
 - Kingman Douglass (1896–1971), American investment banker, member of the United States intelligence community
 - Klondike Douglass (1872–1953), American Major League Baseball player born in Boston
 - Lavantia Densmore Douglass (1827–1899), American social reformer
 - Leon Douglass (1869–1940), American inventor
 - Linda Douglass, director of communications for the White House Office of Health Reform in the Obama administration
 - Lewis Henry Douglass (1840–1908), American typesetter and soldier
 - Mabel Smith Douglass (1874–1933), American educator
 - Maurice Douglass, American football player
 - Mike Douglass (American football), American football player
 - Mike Douglass (urban planner), American urban planner and social scientist
 - Pat Douglass, American basketball player and coach
 - Paul Douglass (1905–1988), American academic administrator
 - Ralph Waddell Douglass (1895–1971), American commercial artist and university professor
 - Ramona Douglass, African-American activist
 - Richard Douglass (1746–1828), American militia officer and cooper
 - Robyn Douglass, American actress
 - Samuel T. Douglass (1814–1898), American justice
 - Sara Douglass (1957–2011), Australian author
 - Sarah Hallam Douglass d1773, English-born American stage actress and theatre director
 - Sean Douglass, American baseball player
 - Stephen Douglass, American actor
 - Stu Douglass (born 1990), American-Israeli basketball player
 - Susan L. Douglass, American educator and author
 - William Douglass (engineer), Chief Engineer for the Commissioners of Irish Lights
 - William Douglass (physician) (c. 1691–1752), American physician and pamphleteer
 - William Boone Douglass (born 1864), American lawyer, engineer, surveyor, genealogist and anthropologist
 
See also
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