Charles O'Brien may refer to:
- Charles O'Brien, 5th Viscount Clare (1673–1706)
- Charles O'Brien, 6th Viscount Clare (1699–1761), Irish military officer in French service
- Charles O'Brien, 7th Viscount Clare (1757–1774)
- Charles O'Brien (colonial administrator) (1859–1935), British Governor of the Seychelles (1912–1918) and Barbados (1918–1925)
- Charles O'Brien (cricketer) (1921–1980), Australian cricketer
- Charles F. X. O'Brien (1879–1940), United States Representative from New Jersey
- Charles H. O'Brien (1920–2007), State Senator and judge from Tennessee, United States
- Charles M. O'Brien (1875–1952), Member of the Legislative Assembly of Alberta, Canada (1909–1913)
- Charles P. O'Brien (born 1939), American research scientist
- Charlie O'Brien (born 1960), retired American baseball player
- Charlie O'Brien (racing driver) (born 1955), Australian racing driver
- Charles O'Brien (unionist) (1933-2020), American labor union organizer
See also
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